Newly developed controlled release subcutaneous formulation for tramadol hydrochloride
نویسندگان
چکیده
منابع مشابه
Formulation Optimization of Hydrodynamically Balanced Oral Controlled Release Bioadhesive Tablets of Tramadol Hydrochloride
The directly compressible floating-bioadhesive tablets of tramadol were formulated using varying amounts Carbopol 971P (CP) and hydroxy-propylmethyl cellulose (HPMC), along with other requisite excipients. In vitro drug release profile, floatational characteristics and ex vivo bioadhesive strength using texture analyzer were determined, and systematically optimized using a 3(2) central composit...
متن کاملDevelopment of Osmotically Controlled Oral Drug Delivery Systems of Tramadol Hydrochloride: Effect of Formulation Variables on In Vitro Release Kinetics
Aim: Numerous technologies have been used to control the systemic delivery of a pharmacologically active ingredient in a predetermined, predictable, and reproducible manner. One of the most interesting approaches is osmotically controlled oral drug delivery systems. By optimizing formulation and processing parameters, it is possible to develop osmotic systems to deliver drugs of diverse nature ...
متن کاملDevelopment and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technology.
Extended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was developed and evaluated. Target release profile was selected and different variables were optimized to achieve it. Formulation variables such as the level of swellable polymer, plasticizer and the coat thickness of semipermeable membrane (SPM) were found to markedly affect drug release. TRH release was ...
متن کاملFormulation and Evaluation of Tramadol hydrochloride Rectal Suppositories
Rectal suppositories of tramadol hydrochloride were prepared using different bases and polymers like PEG, cocoa butter, agar and the effect of different additives on in vitro release of tramadol hydrochloride was studied. The agar-based suppositories were non-disintegrating/non-dissolving, whereas PEGs were disintegrating/dissolving and cocoa butter were melting suppositories. All the prepared ...
متن کاملFluoride release from newly developed dental adhesives.
This study compared fluoride release from three fluoride-releasing dental adhesives (Trial KBF Bond, One-up Bond F, Reactmer Bond) and one conventional dental adhesive (Clearfil SE Bond) for 70 days in vitro. From each material, five disk-shaped specimens (diameter: 9.0 mm, height: 1.5 mm) were prepared and immersed in 5 ml of 10 mM phosphate buffered solution (pH 7.0). After 1, 3, 7, 14, 21, 2...
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ژورنال
عنوان ژورنال: Saudi Pharmaceutical Journal
سال: 2018
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2018.01.014